Poxet 90 mg contains dapoxetine, a selective serotonin reuptake inhibitor (SSRI) prescribed for premature ejaculation. When considering its use alongside other medications, it’s essential to be aware of potential interactions:
1. Monoamine Oxidase Inhibitors (MAOIs): Combining dapoxetine with MAOIs can lead to serious reactions, including serotonin syndrome. It’s advised to avoid using dapoxetine within 14 days of stopping an MAOI and vice versa.
2. Other SSRIs or Serotonergic Drugs: Concurrent use with other SSRIs, serotonin-norepinephrine reuptake inhibitors (SNRIs), or medications that increase serotonin levels can heighten the risk of serotonin syndrome. Caution is recommended when combining these drugs.
3. PDE5 Inhibitors (e.g., Sildenafil, Tadalafil): While some studies suggest that tadalafil does not significantly affect the pharmacokinetics of dapoxetine, caution is still advised when combining dapoxetine with PDE5 inhibitors due to potential additive effects on blood pressure.
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4. CNS Active Medications: The combined use of dapoxetine with central nervous system (CNS) active drugs, such as antipsychotics or anticonvulsants, has not been extensively studied. Therefore, caution is advised when these medications are used together.
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5. CYP3A4 Inhibitors: Medications that inhibit the CYP3A4 enzyme can increase dapoxetine levels in the blood, potentially leading to enhanced side effects. It’s recommended to avoid strong CYP3A4 inhibitors or adjust the dapoxetine dose accordingly.
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6. Alcohol: Combining dapoxetine with alcohol can increase the risk of neurocardiogenic adverse events, such as syncope, and may enhance alcohol-related effects like sedation. It’s advisable to avoid alcohol while taking dapoxetine.
7. Recreational Drugs: Using recreational drugs alongside dapoxetine can lead to serious adverse reactions. For instance, combining dapoxetine with drugs like MDMA (ecstasy) or LSD can increase the risk of serotonin syndrome.
8. Herbal Supplements: Certain herbal supplements, such as St. John’s Wort, can interact with dapoxetine, potentially reducing its effectiveness or increasing side effects. It’s important to inform your healthcare provider about any herbal products you’re using.
Recommendations:
Consult Your Healthcare Provider: Before starting Poxet 90 mg, discuss all current medications, including over-the-counter drugs and supplements, with your doctor to assess potential interactions.
Monitor for Side Effects: Be vigilant for symptoms like dizziness, nausea, or mood changes, and report them to your healthcare provider promptly.
Avoid Alcohol and Recreational Drugs: These substances can exacerbate side effects and increase the risk of serious reactions when combined with dapoxetine.
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