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  • #17709

    stephenbarkin
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    Malegra contains Sildenafil, which is a phosphodiesterase type 5 (PDE5) inhibitor. Here’s how it works to enhance blood flow to the penis:

    Mechanism of Action: Malegra inhibits the PDE5 enzyme, which is responsible for breaking down cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the penis. cGMP is a molecule that helps relax the blood vessels in the penis, allowing increased blood flow.

    Sexual Stimulation: Sildenafil enhances the effects of nitric oxide (NO), a natural chemical released during sexual stimulation. Nitric oxide stimulates the production of cGMP, which relaxes the blood vessels and increases blood flow to the penis.

    Increased Blood Flow: By inhibiting PDE5, Sildenafil prevents the breakdown of cGMP, allowing it to accumulate and continue its effects. This results in the relaxation of smooth muscle and dilation of blood vessels in the penis, leading to improved blood flow and an erection.

    Erection Facilitation: The increased blood flow helps achieve and maintain an erection in response to sexual stimulation. Sildenafil alone does not cause an erection but enhances the body’s natural response to sexual arousal.

    Onset and Duration: Sildenafil typically starts working within 30 to 60 minutes after ingestion, and its effects can last for up to 4 to 6 hours. It’s taken as needed before sexual activity.

    Overall, Malegra works by improving the physiological processes that lead to an erection, making it effective for treating erectile dysfunction.

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